解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas and its relation with the pituitary dopamine receptor 2 (D2R) are not well defined. We sought to dete...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-6-4
更新日期:2007-01-12 00:00:00
abstract:BACKGROUND:Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppression by VHL requires the negative regulation of hypoxia inducible factor alpha (HIF alpha) protein a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-66
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:In polymorphonuclear leukocytes (PMNL), mobilization of calcium ions is one of the early events triggered by binding of chemoattractant to its receptors. Besides chemotaxis, a variety of other functional responses are dependent on calcium ion mobilization. PMNL from chronic myeloid leukaemia (CML) patients t...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-65
更新日期:2006-11-27 00:00:00
abstract::The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer. ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/1476-4598-5-60
更新日期:2006-11-08 00:00:00
abstract::Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various protei...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/1476-4598-5-43
更新日期:2006-10-06 00:00:00
abstract:BACKGROUND:Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a large range of normal and tumour tissues from different collections utilising molecular biological a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-41
更新日期:2006-10-05 00:00:00
abstract:BACKGROUND:Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome segregation fidelity and preventing aneuploidy. Alteration of p53 and pRb function...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-38
更新日期:2006-09-20 00:00:00
abstract:BACKGROUND:Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and it is associated with an elevated risk for malignant tumors of tissues derived from neural crest cells. The NF1 gene is considered a tumor suppressor gene and inactivation of both copies can be found in NF1-associated be...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-36
更新日期:2006-09-10 00:00:00
abstract:BACKGROUND:Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. RESULTS:Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N-terminus. The most abundant isoform we ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-18
更新日期:2006-05-16 00:00:00
abstract::Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a non-aggressive technique that is well accepted by the patient, and is therefore an attractive option for the early diagnosis of...
journal_title:Molecular cancer
pub_type: 杂志文章,收录出版,评审
doi:10.1186/1476-4598-5-11
更新日期:2006-03-23 00:00:00
abstract:BACKGROUND:The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and postmitotic neurons indicate that the activity of cyclin D1 may be regulated through its cytoplasmic se...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-5-7
更新日期:2006-02-17 00:00:00
abstract::Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important con...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/1476-4598-4-36
更新日期:2005-09-13 00:00:00
abstract:BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-4-21
更新日期:2005-06-21 00:00:00
abstract:BACKGROUND:Amplifications at 6p22.3 are prevalent in advanced stage bladder cancer (TCC). Previous studies have identified SOX4, CDKAL, and E2F3 as targets of this amplification and therefore potential oncogenes, but the more telomeric DEK gene too has been reported as overexpressed and amplified. We have therefore inv...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-4-16
更新日期:2005-05-05 00:00:00
abstract:BACKGROUND:Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development. METHODS:We examined ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-3-33
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in mice has led to the development of a number of abnormalities in the male reproductive system, inc...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-3-31
更新日期:2004-11-17 00:00:00
abstract:BACKGROUND:The expression of the rodent phosphoinositide-specific phospholipase C delta-4 (PLCdelta4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCdelta4 expression with rapid proliferation in certain rat transformed cell lines. The human homologue ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-3-15
更新日期:2004-05-13 00:00:00
abstract:BACKGROUND:Recognition of pathogens by immune receptors leads to activation of macrophages, dendritic cells, and lymphocytes. Signals are communicated to enhance expression of target molecules such as cytokines and adhesion molecules, depending on activation of various inducible transcription factors, among which the f...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-2-39
更新日期:2003-11-05 00:00:00
abstract:BACKGROUND:SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monok...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-2-22
更新日期:2003-04-15 00:00:00
abstract::The early diagnosis of pancreatic cancer, as well as distinguishing between chronic pancreatitis and malignant pancreatic disease, remains still a clinical problem. Presently, there is no specific tumor marker for diagnosing pancreatic cancer. Mucin-associated marker like CA 19-9 are the most widely available pancreat...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-07 00:00:00
abstract:INTRODUCTION:Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cel...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-1-4
更新日期:2002-10-04 00:00:00